THE EFFECTS OF SUBMUCOSAL EPİNEPHRINE INJECTION IN ENDOSCOPIC PROCEDURES ON CARDIOVASCULAR SYSTEM
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Abstract
Objectives: The purpose of this study is to investigate the cardiac safety of epinephrine injections into the gastrointestinal tract submucosa.
Methods: The patients who underwent endoscopy and had epinephrine injected for bleeding control, as well as a control group who underwent endoscopy but did not receive epinephrine, were included in the study. Systolic and diastolic blood pressure (mmHg) and heart rate (beats) were measured at 0, 3, 6, 9, and 12 minutes after epinephrine injection in 1/1000, 1/10,000, and 1/20,000 concentrations of patients, and similarly, without administration of epinephrine in the control group.
Results: The change in systolic and diastolic blood pressure values over time was not significant in the groups that received the epinephrine dose (p=0.059, p=0.117). Similarly, no significant difference was found between groups with different epinephrine concentrations in the same minute (p=0.889). There was no significant difference in heart rate values between all groups (p=0.390).
Conclusion: In this study, epinephrine was found to be cardiovascularly safe in cases where it was necessary to exceed the daily dose used in extraesophageal procedures.
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