FORMULATION AND EVALUATION OF SERUM CONTAINING POLYHERBAL EXTRACTS OF CINNAMOMUM CASSIA & ALOE VERA FOR THE TREATMENT OF WOUND INFECTION

Abstract

Herbal formulations continuously have attracted substantial attention because of their good activity and relatively lesser or not as much of side effects with synthetic drugs.  The herbal cosmetics manufactured and used usually for the daily purposes include herbal face wash, herbal hair gel, herbal soap, herbal shampoo, etc. the industry is now concentrating on the growing segment with a vast scope of various expansion in coming years. In the Indian system of medicines-Ayurveda Aloevera, Cinnamommum cassia has been mentioned as a remedy for treating wound injuries and infectious diseases. Wound occurs due to disruption of soft tissues that results from injury. Based on the folkloric use, the present study was designed to formulate and evaluate polyherbal gel containing extracts of Aloevera and Cinnamommum cassia..The Phtochemical (Secondary metabolites) screening of extracts are done which consists of alkaloid, Flavonoids, steroids or triterpenoids, phenols, carbohydrate and quantification of plants are done. Formulated gel were prepared which comprised of the methanolic extracts of Aloevera leaves and Cinnmommum cassia bark in concentration of 50% and 9% respectively in a base. It also consists of Sandalwood oil which is used for providing aroma to     serum. The phytochemicals are majorly take part in wound healing. The prepared formulations were evaluated for appearance and homogeneity, pH, aroma, spreadability, ash, stability. The formulation is also screened for their antimicrobial activity by disc plate method against S.aureus. The results of studies revealed that formulation under showed better zone of inhibition as compared with the control. The formulated polyherbal gel were observed to possess antimicrobial action. The effective activity may be attributed to the synergistic action of the plants constituents present in the formulation. The formulated serum shows increased antimicrobial activity by 0.5%. An attempt was made to give an insight into the reported medicinal plants with wound healing mechanisms which could be beneficial in therapeutic practice and development of new wound healing serum for human use.