International Journal of Medical Sciences and Academic Research

A Review of the Optimized Curve-Protected Cap Dispenser: A Solution for Safer, Sterile, and Cost-Efficient Guidewire Management

Sun, 11 May 2025 00:00:00 +0000

Guidewires are slender, flexible tools that play a vital role in modern medical procedures, helping doctors navigate catheters and other devices safely through the body’s complex pathways. They're essential for the success of many minimally invasive treatments. But despite their importance, guidewires—especially those with curved tips—are surprisingly fragile. The delicate ends can easily get bent or damaged during routine handling or storage, which not only affects their performance but also leads to unnecessary replacements and added costs.To tackle this challenge, a specially designed cap dispenser has been introduced. This simple yet smart solution helps protect the guidewire’s tip and maintain its shape and functionality. The cap dispenser includes key features like a protective dispenser tube, a secure e-clip, a curve protector to shield the curved end, and a tip straightener that gently aligns the wire when needed. Together, these components make the guidewire safer to use, easier to handle, and more reliable in clinical settings.At the distal end of the dispenser, a protective cap securely shields the curved tip of the guidewire, protecting it from damage, contamination, or deformation. The cap is attached to a tip straightener, which ensures proper alignment of the guidewire, providing stability during storage and supporting smooth retrieval. This thoughtful design enhances the overall stability of the guidewire within the dispenser, streamlining the removal process for physicians and reducing the risk of damage.By offering both alignment and protection, this curve-protected cap dispenser not only ensures that the guidewire remains in optimal condition throughout storage and handling but also significantly improves procedural efficiency. These protective features go a long way in preventing the kind of damage that often leads to expensive guidewire replacements. By keeping the delicate tips intact, the cap dispenser helps hospitals and clinics save money over time. But it’s not just about cost—its straight forward design also makes life easier for healthcare providers. With quicker, safer access to the guidewire, clinicians can focus more on patient care and less on equipment issues, helping procedures run more smoothly and efficiently. It's a small tool that makes a big difference in both workflow and overall operating costs.

Investigating the Impact of Diabetes-Related Complications on Quality of Life in Diabetic Patients

Hemanggie Joshi — Thu, 08 May 2025 00:00:00 +0000

Diabetes patients deal with serious problems that might impair their quality of life. Knowing how diabetes complications impact quality of life is essential to improving patient care and results. The quality of life and consequences associated with diabetes are examined in this systematic study. We looked for research from 2013 to 2023 using PubMed, Scopus, Web of Science, and Google Scholar. "Diabetes Mellitus," "Diabetes Complications," together with "Quality of Life." Included were studies that assessed adult diabetics' quality of life and complications. Data extraction and quality assessment were done using PRISMA. In all, 7,500 people with diabetes from various countries participated in 18 studies. Most studies found that cardiovascular disease, peripheral vascular disease, neuropathy, nephropathy, and retinopathy were linked to considerably worse QoL ratings, especially in the physical and psychological domains. The length of the sickness and comorbidities caused QoL to progressively decrease. Complications significantly lower the quality of life for diabetics. Certain treatments for these issues might improve quality of life. Pharmacists support patient education, treatment, and early detection.

Guidance for Endoscopy during COVID-19 Pandemic by Bangladesh Medical University Hepatology Alumni Association and It’s Validation

Prof. Mamun Al Mahtab — Sun, 11 May 2025 00:00:00 +0000

Coronavirus disease-2019 (COVID-19) was declared a pandemic by World Health Organization in early 2020 and the world went into lock-down soon after, which disrupted all spheres of normal life including healthcare delivery. Likewise endoscopy services in Bangladesh was hugely disturbed, which demanded adaptation of safety measures to restart endoscopy during the pandemic.

Methods: This need prompted the Bangladesh Medical University Hepatology Alumni Association to adopt standard operating procedure (SOP) to ensure safe delivery of such services to patients in need. The association also decided to test this SOP to assess it’s safety and efficacy.

Results: The SOP was tested in a private sector tertiary care center where more than 5,300 endoscopic procedures were performed between April 2020 to December 2021. Results show that only 5 endoscopy staff and 400 patients developed COVID-19, none severe.

Conclusion: The study shows that the SOP adopted by the association was safe and effective and will be useful as we prepare to face the next pandemic sometime in the future.

Clinical Pathological Disturbances of Zinc Oxide Nanoparticles-Induced Acute Hepatotoxicity in Time Manner in Rats

Ozdan Akram Ghareeb — Thu, 08 May 2025 00:00:00 +0000

The liver is the key to clearing and detoxification chemical toxins in the body, so it is the most susceptive to toxicity. Despite rapid advances in nanotechnology, it has not yet been adequately approved by toxicological estimations. Therefore, this study was prepared to assess the acute hepatotoxicity on clinical pathology parameters caused by zinc oxide nanoparticles (ZnONPs) in in vivo experiment. Twenty-four male rats were consumed in this experiment, separated into three groups (eight in each).First group (CON) was served as a control without receiving any dose, whilst other two groups were dosing with ZnONPs (600 mg/kg) once, as(ZnONPs-1) group being euthanized after one day and (ZnONPs-5) group after five days of exposure. To complete clinical pathology analyses, serum was collected for biochemical tests and liver homogenates were isolated to assess oxidative stress status of all studied rats. A considerable increase in serological liver enzymes levels was recorded in ZnONPs-exposed rats, which was time-dependent compared to unexposed rats. Moreover, ZnONPs induced an increase in malondialdehyde levels in liver homogeneous with a significant inhibition of antioxidant levels over time compared to unexposed rats. In conclusion, a single exposure to high concentration of ZnONPs induced hepatotoxicity through disturbance of clinical pathology indicators as time-dependent.

Clinical diagnosis of a rare genetic disease: Kabuki syndrome; a case report

Karima Larbi Ouassou, Amal El Hassani, Rachid Abilkassem — Sun, 11 May 2025 00:00:00 +0000

Kabuki syndrome (KS) is a rare, clinically recognizable genetic disorder with autosomal dominant inheritance. The diagnosis is suspected clinically because the phenotype is recognizable and genetic testing is not universally available. This work reports the case of a patient in whom KS was revealed by seizures.