http://scientificpublications.in/index.php/ijmsar/issue/feed 2025-03-20T17:09:51+00:00 International Journal of Medical Sciences and Academic Research editor@scientificpublications.in Open Journal Systems <p style="text-align: justify;"><strong>International Journal of Medical Sciences and Academic Research</strong> is an international open access journal that publishes peer-reviewed scholarly articles on all the areas of Medical Sciences. Its goal is to serve international scientific and clinical communities, to strengthen links between science and policy and to stimulate and enhance the quality of debate. In addition to original research work, the journal features editorials, commentaries, review, letters a, theoretical, research papers, state-of-the-science reviews, descriptions, research on scientific behaviours to evidence-based clinical practice. The Journal is using Editorial Manager System for easy online tracking and managing of the manuscript processing. Each article undergoes a peer-review process under the aegis of an assigned Editor.</p> <p style="text-align: justify;"><strong>International Journal of Medical Sciences and Academic Research</strong> Open-access &amp; e-journal Free-flow of the information is necessary in this world. Open-access leads to more citation and hence more recognition for our esteemed authors. Critical and positive peer-review the decisions of the reviewers are unbiased and whatever is the decision is conveyed to the authors.</p> http://scientificpublications.in/index.php/ijmsar/article/view/93 2025-03-04T01:24:04+00:00 Mamun Al Mahtab shwapnil@agni.com

<p style="text-align: justify;"><strong><em>Background:</em></strong> Barrett’s oesophagus is recognized cause of oesophageal carcinoma. Currently different endoscopic treatment modalities are being adopted and evaluated to manage Barrett’s mucosa to prevent subsequent malignant transformation.</p> <p style="text-align: justify;"><strong><em>Methods: </em></strong>We have recently introduced argon plasma coagulation at endoscopy of upper gastrointestinal tract for Barrett’s oesophagusmanagement in Bangladesh.</p> <p style="text-align: justify;"><strong><em>Results: </em></strong>The study included 30 Barrett’s oesophagus patients who underwent argon plasma coagulation by a senior Endoscopist. We observed complete eradication of Barrett’s oesophagus in 83.3% cases, while reduction of Barrett’s mucosal length was seen in 90%.</p> <p style="text-align: justify;"><strong><em>Conclusion: </em></strong>Argon plasma coagulation appears to be safe and effective for Barrett’s oesophagus management. However further work is needed to reach a conclusive statement.</p>

2025-03-19T00:00:00+00:00 Copyright (c) 2025 Mamun Al Mahtab http://scientificpublications.in/index.php/ijmsar/article/view/94 2025-03-20T17:09:51+00:00 Prof. Orien L Tulp o.tulp@usat.edu

<p style="text-align: justify;">To determine the effects of epigenetic predisposition of early onset obesity,aging and T2DM on glycemic parameters, groups of congenic male lean, obese, and obese-diabetic rats (n= 5-6 rats/group) that share the same genetic trait for obesity (the <em>-cp</em> trait) were reared under normal laboratory conditions and fed stock Purina Rodent chow<em>ad libitum</em> throughout. Rats were subjected to measures of fasting glucose, insulin, amylin, insulin:glucose ratios, and glycated hemoglobin concentrations and on the glycemic response to an oral glucose tolerance (OGT) and Area Under the curve (AUCglc) at 4 and again at 12 months of age. Obese animals weighed more than their lean littermates (p = &lt; 0.05). Fasting plasma glucose, insulin, and amylin concentrations of obese &gt; lean, and in increased further in NIDDM-prone animals, with the greatest increases in the oldest animals. Hemoglobin A1c trended higher in obese than in lean littermates and was markedly greater in the NIDDM-prone animals of both ages.(p = &lt; 0.05) Oral glucose tolerance and AUCglcof obese &gt; lean, and was markedly greater in NIDDM-prone animals, with the greatest increase in the oldest animals. The AUCglc was greater in obese than in lean littermates and increased significantly on T2DM-prone animals at both ages. In conclusion, these results demonstrate the effects of aging on the obese trait on development and expression of insulin resistance may occur independently of T2DM in these closely related congenic strains and that the glycemic responses deteriorate further with aging when left untreated. </p>

2025-03-29T00:00:00+00:00 Copyright (c) 2025 Prof. Orien L Tulp